TABLE 1

Activities of ceftolozane-tazobactam and comparator agents against Burkholderia strains

Species or group (na)Antibiotic(s)MICs (μg/ml)
RangeMIC50MIC90
Burkholderia, all isolates (221)Ceftolozane-tazobactam≤0.25 to >64232
Amikacin≤16 to >6464>64
Aztreonam≤4 to >3216>32
Ceftazidime≤0.5 to >64416
Chloramphenicol≤8 to >321632
Ciprofloxacin≤2 to >8≤2>8
Doripenem≤1 to >848
Levofloxacin≤1 to >8≤1>8
Meropenem≤1 to >1628
Minocycline≤1 to >1628
Piperacillin-tazobactam≤4 to >128≤4128
Tigecycline≤2 to 16≤28
Tobramycin≤2 to >16>16>16
Trimethoprim-sulfamethoxazole≤1 to >8≤12
Burkholderia multivorans (50)Ceftolozane-tazobactam0.5 to >641>64
Amikacin≤16 to >6464>64
Aztreonam≤4 to >32≤4>32
Ceftazidime1 to >64264
Chloramphenicol≤8 to >32≤832
Ciprofloxacin≤2 to >8≤2>8
Doripenem≤1 to >848
Levofloxacin≤1 to >8≤1>8
Meropenem≤1 to >164>16
Minocycline≤1 to 16<14
Piperacillin-tazobactam≤4 to >128≤4>128
Tigecycline≤2 to 16≤28
Tobramycin≤2 to >16>16>16
Trimethoprim-sulfamethoxazole≤1 to 8≤12
Burkholderia cenocepacia (42)Ceftolozane-tazobactam≤0.25 to >64132
Amikacin≤16 to >64>64>64
Aztreonam≤4 to >3216>32
Ceftazidime1 to >64416
Chloramphenicol≤8 to >3216>32
Ciprofloxacin≤2 to >8≤2>8
Doripenem≤1 to >84>8
Levofloxacin≤1 to >82>8
Meropenem≤1 to 1628
Minocycline≤1 to >16216
Piperacillin-tazobactam≤4 to >1288128
Tigecycline≤2 to 16≤216
Tobramycin8 to >16>16>16
Trimethoprim-sulfamethoxazole≤1 to 8≤14
Burkholderia vietnamiensis (22)Ceftolozane-tazobactam≤0.25 to 3214
Amikacin≤16 to >64≤16>64
Aztreonam≤4 to >32≤416
Ceftazidime1 to 1624
Chloramphenicol≤8 to >3216>32
Ciprofloxacin≤2 to >8≤24
Doripenem≤1 to 8≤14
Levofloxacin≤1 to >828
Meropenem≤1 to 4≤14
Minocycline≤1 to 824
Piperacillin-tazobactam≤4 to 128≤416
Tigecycline≤2 to >16≤24
Tobramycin≤2 to >168>16
Trimethoprim-sulfamethoxazole≤1 to >8≤18
Burkholderia cepacia (22)Ceftolozane-tazobactam0.5 to 414
Amikacin32 to >6432>64
Aztreonam8 to >3216>32
Ceftazidime2 to 1648
Chloramphenicol≤8 to >321632
Ciprofloxacin≤2 to 4≤2≤2
Doripenem4 to 848
Levofloxacin≤1 to 824
Meropenem2 to 844
Minocycline≤1 to 1624
Piperacillin-tazobactam≤4 to 128832
Tigecycline≤2 to 16≤24
Tobramycin16 to >16>16>16
Trimethoprim-sulfamethoxazole≤1≤1≤1
Other Bcc spp.b (39)Ceftolozane-tazobactam≤0.25 to >64216
Amikacin≤16 to >6464>64
Aztreonam≤4 to >3216>32
Ceftazidime≤0.5 to >64416
Chloramphenicol≤8 to >321632
Ciprofloxacin≤2 to >8≤24
Doripenem≤1 to >848
Levofloxacin≤1 to >8≤14
Meropenem≤1 to >1648
Minocycline≤1 to >1628
Piperacillin-tazobactam≤4 to 1288128
Tigecycline≤2 to 16≤28
Tobramycin≤2 to >16>16>16
Trimethoprim-sulfamethoxazole≤1 to 4≤1≤1
Burkholderia gladioli (46)Ceftolozane-tazobactam2 to 32816
Amikacin≤16 to 64≤16≤16
Aztreonam16 to >3232>32
Ceftazidime1 to 641616
Chloramphenicol≤8 to >323232
Ciprofloxacin≤2 to >8≤2≤2
Doripenem≤1 to 4≤12
Levofloxacin≤1 to >8≤12
Meropenem≤1 to 8≤12
Minocycline≤1 to 1624
Piperacillin-tazobactam≤4 to 64≤4≤4
Tigecycline≤2 to 16≤2≤2
Tobramycin≤2 to >16≤2≤2
Trimethoprim-sulfamethoxazole≤1 to 2≤1≤1
  • a Number tested in each category.

  • b Includes (number of isolates) Burkholderia contaminans (11), Burkholderia dolosa (10), Burkholderia ambifaria (9), and Burkholderia stabilis (9).