TABLE 1.

IC50 values for inhibitor compounds

GroupCompoundMean IC50 ± SDb
11 (MTX)0.024 ± 0.021
2a0.27 ± 0.10
31.1 ± 0.34
40.60 ± 0.11
51.67 ± 0.98
6a0.51 ± 0.51
7a0.88 ± 0.13
8a0.35 ± 0.035
91.85 ± 0.29
101.90 ± 1.36
114.82 ± 1.16
126.32 ± 5.29
132.26 ± 1.73
147.58 ± 1.70
1517.61 ± 0.78
16>1 mM
1716.67 ± 0.33
18252.2 ± 19.2
219 (TMP)42.96 ± 9.20
2037.33 ± 2.58
2169.29 ± 24.4
2273.73 ± 13.1
23150.23 ± 13.1
24 (PYRc)>1 mM
325>1 mM
26>1 mM
27>1 mM
  • a Inhibitor tested in vivo.

  • b IC50 values are expressed in μM unless otherwise noted.

  • c PYR, pyrimethamine.