TABLE 2.

Cefepime population pharmacokinetic parametersa

ParameterV1 (liters)Kcp (h−1)Kpc (h−1)CLi (liters/h)CLs
Mean22.9711.2035.630.3890.0628
Median27.0812.5841.090.3290.0551
SD15.568.06919.480.3540.0324
  • a CL = CLi + (CLs × CLCR). Kcp, rate constant from the central compartment to the peripheral compartment; Kpc, rate constant from the peripheral compartment to the central compartment.