TABLE 1.

Semiquantitative results of organ cultures of rabbits treated with antifungal therapy begun 24 h after challenge

GroupgLog10 geometric mean CFU/g [95% CIf] (no. of positive cultures/no. of rabbits cultured)
SpleenKidneyLiverLungBrain
Control2.17 [2.15-2.27] (8/8)3.94 [3.5-4.71] (8/8)2.01 [1.54-2.48] (8/8)2.82 [2.68-2.94] (8/8)2.42 [1.50-3.34] (8/8)
AMB1.43 [0.91-1.95]c (6/8)3.44 [2.88-4.00] (8/8)0.58 [−0.32-1.47]c (2/8)1.70 [0.17-3.22] (4/8)0.95 [−5.22-2.43] (2/8)
ABC 150b,d (0/8)2.94 [2.21-3.71] (8/8)0d (0/8)0a,d (0/8)1.08 [0.10-2.07] (4/8)
ABC 250b,d (0/8)3.21 [2.80-3.44] (8/8)0d (0/8)0a,d (0/8)1.11 [0.11-2.10] (4/8)
ABC 500b,d (0/8)0.33 [−0.27-0.95]b,d (1/8)0d (0/8)0a,d (0/8)0.42 [−0.23-1.08]c (2/8)
  • a P < 0.007 versus values obtained with AMB.

  • b P < 0.001 versus values obtained with AMB.

  • c P < 0.012 versus values obtained with control.

  • d P < 0.001 versus values obtained with control.

  • e P = 0.023 versus values obtained with control.

  • f CI, confidence interval.

  • g Drug and dose in milligrams/kilogram/day are given.