TABLE 1.

MICs of various compounds for S. pneumoniae QA1442 and its mutants

StrainMIC (μg/ml)
SB-362916TetracyclineChloramphenicolaErythromycin
QA1442>640.540.125
QA1442 ΔmetS1>640.54>64
QA1442 ΔmetS240.5320.125
QA1442 QS140.540.125
QA1442 QS240.540.125
  • a The increased MICs of erythromycin and chloramphenicol for QA1442 ΔmetS1 and QA1442 ΔmetS2, respectively, are due to the resistance cassette used for gene disruption.