TABLE 3.

In vitro activities of DX-619 and other reference compounds against clinical isolates of anaerobic bacteria and facultative anaerobic bacteria

Organism group (no. of isolates)AntibioticMIC (μg/ml)% Susceptible at concn (μg/ml) of:
RangeMIC50MIC90≤2≤4≤8≤16
Bacteroides distasonis (25)DX-619≤0.03-40.06196.0100.0100.0100.0
Ceftriaxone1->128128>12816.020.020.028.0
Cefmetazole16->128641280.00.00.08.0
Imipenem1-41484.0100.0100.0100.0
Clindamycin≤0.03->1284>12816.056.064.064.0
Levofloxacin0.5-12816468.072.072.076.0
Bacteroides fragilis (25)DX-6190.06-40.1250.596.0100.0100.0100.0
Ceftriaxone1->1288>12816.024.052.052.0
Cefmetazole8-328160.00.056.096.0
Imipenem0.125-20.51100.0100.0100.0100.0
Clindamycin0.125->1281>12868.068.068.068.0
Levofloxacin1-6426472.084.088.088.0
Bacteroides thetaiotaomicron (25)DX-6190.06-10.1250.5100.0100.0100.0100.0
Ceftriaxone64->128>128>1280.00.00.00.0
Cefmetazole64-128641280.00.00.00.0
Imipenem0.25-211100.0100.0100.0100.0
Clindamycin1->1288>12824.048.052.052.0
Levofloxacin4-644160.086.088.092.0
Prevotella spp. (42)aDX-6190.125-10.251100.0100.0100.0100.0
Ceftriaxone≤0.03->12813254.857.169.088.1
Cefmetazole0.06-160.5483.397.697.6100.0
Imipenem≤0.03-0.250.060.125100.0100.0100.0100.0
Clindamycin≤0.03->128≤0.03≤0.0392.992.992.992.9
Levofloxacin0.5-160.5297.697.697.6100.0
Fusobacterium spp. (25)bDX-619≤0.03-0.50.060.25100.0100.0100.0100.0
Ceftriaxone≤0.03-32≤0.03292.092.096.096.0
Cefmetazole0.06-160.25880.088.096.0100.0
Imipenem≤0.03-40.25484.0100.0100.0100.0
Clindamycin≤0.03-320.06888.088.096.096.0
Levofloxacin0.5-41292.0100.0100.0100.0
Micromonas micros (25)DX-619≤0.03≤0.03≤0.03100.0100.0100.0100.0
Ceftriaxone0.125-80.25192.096.0100.0100.0
Cefmetazole0.25-160.5192.092.096.0100.0
Imipenem0.25-20.50.5100.0100.0100.0100.0
Clindamycin0.125-160.250.596.096.096.0100.0
Levofloxacin0.25-0.50.50.5100.0100.0100.0100.0
Actinomyces spp. (15)cDX-6190.06-20.1251100.0100.0100.0100.0
Ceftriaxone≤0.03-80.25486.793.3100.0100.0
Cefmetazole≤0.03-160.25880.086.793.3100.0
Imipenem≤0.03-81873.373.3100.0100.0
Clindamycin0.125->1280.25193.393.393.393.3
Levofloxacin0.25-88820.046.7100.0100.0
Propionibacterium acnes (10)DX-6190.1250.1250.125100.0100.0100.0100.0
Ceftriaxone≤0.03-0.125≤0.030.06100.0100.0100.0100.0
Cefmetazole0.06-0.250.1250.25100.0100.0100.0100.0
Imipenem≤0.03-0.06≤0.030.06100.0100.0100.0100.0
Clindamycin≤0.03-0.25≤0.030.25100.0100.0100.0100.0
Levofloxacin0.25-80.50.590.090.0100.0100.0
Clostridium difficile (27)DX-6190.125-20.1251100.0100.0100.0100.0
Ceftriaxone8->12864>1280.00.03.77.4
Cefmetazole8->12832640.00.04.229.2
Imipenem2-648164.216.775.091.7
Clindamycin4->1288.0>1280.020.862.562.5
Levofloxacin4->1284>1280.050.054.258.3
Clostridium perfringens (25)DX-619≤0.03-0.250.060.25100.0100.0100.0100.0
Ceftriaxone≤0.03-20.1251100.0100.0100.0100.0
Cefmetazole0.06-0.50.1250.25100.0100.0100.0100.0
Imipenem0.06-0.250.1250.25100.0100.0100.0100.0
Clindamycin≤0.03->1282484.092.092.092.0
Levofloxacin0.25-320.5196.096.096.096.0
Other Clostridium spp. (14)DX-619≤0.03-0.06≤0.03≤0.03100.0100.0100.0100.0
Ceftriaxone≤0.03-80.25885.785.7100.0100.0
Cefmetazole≤0.03-0.50.1250.25100.0100.0100.0100.0
Imipenem≤0.03-0.25≤0.030.25100.0100.0100.0100.0
Clindamycin≤0.03-32≤0.033285.785.785.785.7
Levofloxacin0.06-10.1250.5100.0100.0100.0100.0
  • a Includes 28 P. intermedia/nigrescens and 10 P. melaninogenica isolates and 4 isolates from other Prevotella spp.

  • b Includes 10 F. nucleatum, 8 F. necrophorum, and 5 F. varium/mortiferum isolates and 2 isolates from other Fusobacterium spp.

  • c One A. gerencseriae, two A. israelii, three A. meyeri, four A. naeslundii, and seven A. odontolyticus isolates.