TABLE 3.

Association between mutations in PBPs and antimicrobial susceptibility

Antibiotics and strain groups testedaMIC (μg/ml)
50%90%Range
Penicillin
    I0.120.250.12-0.25
    II120.25-2
    III240.25-4
Ceftriaxone
    I0.0040.0080.004-0.016
    II0.030.030.004-0.06
    III0.060.120.016-0.12
Cefixime
    I0.0080.0160.008-0.03
    II0.030.030.008-0.03
    III0.250.50.12-0.5
Ceftibuten
    I0.030.060.03-0.12
    II0.060.120.03-0.12
    III882-8
Cefpodoxime
    I0.030.060.016-0.12
    II0.120.250.016-0.5
    III240.5-4
Cefdinir
    I0.0080.030.008-0.03
    II0.030.060.008-0.06
    III110.5-1
Cefcapene
    I0.0160.060.008-0.06
    II0.120.250.008-0.25
    III120.12-4
Cefditoren
    I0.030.060.008-0.12
    II0.120.250.004-0.5
    III0.250.50.016-0.5
  • a Strains were classified into three groups according to the mutations in PBP1 and PBP2 (Table 2). Group I, n = 10; group II, n = 20; group III, n = 28.