TABLE 3.

Hypothesis testing for factors affecting pharmacokinetics of arbekacin

QuestionModel comparedOBJΔOBJ (−2l.l.d.)aP value
Full modelb2,949.705
Is CL proportional to CLCR?
    CLCR < 80 ml/minFull model vs θ1 = 03,094.280144.575<0.001
    CLCR ≥ 80 ml/minFull model vs θ5 = 02,963.97414.269<0.001
Is CL proportional to patient WT? (CLCR ≥ 80 ml/min)Full model vs θ6 = 02,968.59118.886<0.001
Is CL inversely proportional to age?Full model vs θ7 = 02,971.77722.072<0.001
Do patients with pneumonia or sepsis have different V1 values?Full model vs θ8 = 13,006.22856.523<0.001
Do patients with other infections have different V1 values?Full model vs θ9 = 12,969.43419.729<0.001
Full model vs θ9 = θ82,954.7175.0120.025
Do elderly people have different V1 values?Full model vs θ10 = 12,955.6655.9600.014
Do patients with infectious diseases other than pneumonia have different V2 values?Full model vs θ11 = 12,972.81623.111<0.001
Do patients with pneumonia have different V2 values?Full model vs θ12 = 12,953.5243.8190.05
Full model vs θ12 = θ112,966.09716.392<0.001
  • a −2l.l.d., −2(log likelihood difference).

  • b CL = θ1CLCR + (θ7/age) (CLCR < 80 ml/min), CL = θ5CLCR + θ6WT + (θ7/age) (CLCR ≥ 80 ml/min) V1 healthy = θ2WT, V1 = θ8V1 healthy (pneumonia or sepsis), V1 = θ9V1 healthy (infections other than pneumonia and sepsis), V1 elderly = θ10V1 nonelderly, V2 healthy = θ3, V2 = θ11V2 healthy (except pneumonia), V2 = θ12V2 healthy (pneumonia), Q = θ4.