TABLE 3.

Bactericidal activity of combinations of vancomycin and oxacillin against NY-VRSA and VRSA-5 strains

Concn (μg/ml) of:Decrease of bacterial count (in log10 CFU/ml) after 24 h for straina:
VancomycinOxacillinNY-VRSAVRSA-5
112.5 ± 0.171.4 ± 0.10
22.9 ± 0.051.5 ± 0.30
43.6 ± 0.321.9 ± 0.18
84.3 ± 0.122.1 ± 0.08
20.52.6 ± 0.301.6 ± 0.16
12.9 ± 0.022.1 ± 0.05
24.4 ± 0.212.2 ± 0.06
44.2 ± 0.132.5 ± 0.06
84.8 ± 0.152.7 ± 0.27
40.53.5 ± 0.161.4 ± 0.10
13.7 ± 0.241.3 ± 0.16
24.3 ± 0.101.6 ± 0.31
44.3 ± 0.192.1 ± 0.16
84.7 ± 0.262.9 ± 0.03
80.53.9 ± 0.051.5 ± 0.36
14.3 ± 0.071.4 ± 0.13
24.4 ± 0.552.1 ± 0.10
44.8 ± 0.082.1 ± 0.09
85.4 ± 0.153.0 ± 0.03
160.53.5 ± 0.043.1 ± 0.09
14.5 ± 0.043.2 ± 0.11
24.2 ± 0.103.2 ± 0.06
44.8 ± 0.113.5 ± 0.16
85.3 ± 0.224.5 ± 0.07
320.53.6 ± 0.263.2 ± 0.04
14.4 ± 0.553.2 ± 0.08
24.5 ± 0.473.4 ± 0.21
44.9 ± 0.074.3 ± 0.53
85.4 ± 0.094.4 ± 0.15
  • a Shown are means (±standard deviations) of three independent experiments.