TABLE 1.

Antimicrobial activities of DX-619 and other reference compounds against gram-positive anaerobic bacteria and facultative anaerobic bacteria

OrganismMIC (μg/ml)
DX-619CeftriaxoneCefmetazoleImipenemClindamycinLevofloxacinMetronidazole
Anaerococcus prevotii ATCC 93210.12510.50.250.12542
Atopobium parvulum VPI 05460.1250.520.2510.52
Finegoldia magna ATCC 29328≤0.0341220.250.5
Micromonas micros VPI 5464-1≤0.030.250.250.250.250.50.5
Peptoniphilus asaccharolyticus WAL32180.060.250.250.25>12841
Peptoniphilus indolicus GAI09150.06≤0.030.060.53240.5
Peptostreptococcus anaerobius ATCC 27337≤0.030.50.50.060.250.250.125
Gemella morbillorum ATCC 278240.06≤0.030.25≤0.030.061>16
Staphylococcus saccharolyticus ATCC 14953≤0.030.50.5≤0.030.1250.5>16
Streptococcus constellatus ATCC 27923≤0.030.520.1250.251>16
Streptococcus intermedius ATCC 27335≤0.030.2520.50.251>16
Clostridium bifermentans NCTC068000.060.250.250.12511NDa
Clostridium clostridioforme NCTC112240.064160.50.25160.03
Clostridium difficile GAI100290.12532324>12840.25
Clostridium paraputrificum ATCC 257800.0640.50.581ND
Clostridium perfringens ATCC 13124≤0.030.1250.1250.1250.060.250.5
Clostridium putrificum ATCC 25784≤0.0340.250.125320.25ND
Clostridium septicum ATCC 124640.0610.125≤0.03≤0.030.1250.25
Clostridium sordellii NCTC069290.060.250.250.12511ND
Clostridium sordellii NCTC087800.060.250.50.12511ND
Clostridium ramosum ATCC 255820.250.540.25881
Actinomyces odontolyticus GAI910020.250.250.520.25816
Bifidobacterium adolescentis ATCC 157030.50.1250.251≤0.031>16
Bifidobacterium bifidum JCM12550.510.250.25≤0.0384
Bifidobacterium breve ATCC 157000.5242≤0.03816
Bifidobacterium longum subsp. longum ATCC 157071448≤0.0348
Bifidobacterium pseudolongum ATCC 2552610.50.58≤0.038>16
Eggerthella lenta ATCC 255590.125>1281680.250.50.25
Eggerthella lenta ATCC 430550.125>1281640.1250.5ND
Propionibacterium acnes ATCC 118280.1250.510.1250.1250.5>16
Propionibacterium granulosum ATCC 255640.060.12520.125≤0.030.25>16
Lactobacillus acidophilus JCM11320.125180.125132>16
Lactobacillus brevis subsp. brevis JCM10590.06864≤0.03≤0.038>16
Lactobacillus casei subsp. casei JCM1134≤0.034128121>16
Lactobacillus fermentum JCM11730.12564128≤0.03≤0.038>16
Lactobacillus plantarum JCM11490.2500.125>1280.060.258>16
Lactobacillus reuteri JCM11120.0616>1280.06≤0.0316>16
Lactobacillus salivarius subsp. salivarius JCM1231≤0.0343210.061>16
  • a ND, not done.