TABLE 4.

In vitro activities of DX-619 and other reference compounds against resistant anaerobic strains

Organism group (no. of isolates)AntibioticMIC (μg/ml)% Susceptible at concn (μg/ml) of:
RangeMIC50MIC90≤2≤4≤16
Imipenem-resistant B. fragilis group organisms (11)aDX-6190.06-160.25190.990.9100.0
Ceftriaxone16->128128>1280.00.09.1
Cefmetazole16->128641280.00.09.1
Imipenem8->12816>1280.00.036.4
Clindamycin1->128>128>12827.336.436.4
Levofloxacin1-12841627.381.890.9
Levofloxacin-resistant anaerobic gram-positive cocci (14)bDX-6190.125-20.252100.0100.0100.0
Ceftriaxone0.125-160.5864.378.6100.0
Cefmetazole0.125-20.252100.0100.0100.0
Imipenem≤0.03-10.061100.0100.0100.0
Clindamycin≤0.03->1281>12850.057.164.3
Levofloxacin16-128161280.00.042.9
  • a Includes 10 B. fragilis and 1 B. thetaiotaomicron isolate.

  • b Includes five Finegoldia magna, eight Peptoniphilus asaccharolyticus, and one Peptostreptococcus anaerobius isolate.