TABLE 2.

Antimicrobial activities of DX-619 and other reference compounds against gram-negative anaerobic bacteria and facultative anaerobic bacteria

OrganismMIC (μg/ml)
DX-619CeftriaxoneCefmetazoleImipenemClindamycinLevofloxacinMetronidazole
Bacteroides fragilis GAI55620.06880.50.510.5
Bacteroides fragilis ATCC 252850.06880.25110.5
Bacteroides fragilis NCTC105810.06880.125≤0.0310.5
Bacteroides fragilis GAI05580.06>12880.50.510.5
Bacteroides fragilis GAI79550.125>1281288120.25
Bacteroides fragilis GAI101500.06>1286420.510.5
Bacteroides vulgatus ATCC 84820.060.06210.0620.5
Bacteroides distasonis ATCC 85030.060.06210.0620.5
Bacteroides ovatus ATCC 84830.1251281280.250.540.5
Bacteroides thetaiotaomicron ATCC 297410.125128640.5440.5
Bacteroides uniformis ATCC 84920.125220.25≤0.0340.5
Bacteroides eggerthii ATCC 277540.250.540.125≤0.0340.5
Bacteroides ureolyticus NCTC10941≤0.03≤0.030.250.250.250.062
Campylobacter gracilis JCM8538≤0.030.12580.250.1250.060.5
Sutterella wadsworthensis ATCC 515791881160.52
Prevotella bivia ATCC 2930343280.06≤0.0381
Prevotella buccae ATCC 335740.500.520.125≤0.0310.5
Prevotella corporis GAI910000.5010.5≤0.03≤0.0310.125
Prevotella heparinolytica ATCC 35895≤0.030.1250.50.125≤0.0310.06
Prevotella intermedia ATCC 256110.250.1250.250.06≤0.0310.5
Prevotella melaninogenica GAI54900.250.1250.250.06≤0.0310.25
Prevotella oralis ATCC 332690.50.252≤0.03≤0.0320.125
Prevotella oris ATCC 335730.1250.2510.06≤0.030.50.125
Porphyromonas asaccharolytica ATCC 25260≤0.030.060.1250.06≤0.030.50.125
Porphyromonas gingivalis ATCC 33277≤0.03≤0.030.06≤0.03≤0.030.1250.03
Fusobacterium nucleatum ATCC 25586≤0.03110.50.061≤0.015
Fusobacterium varium ATCC 85010.5444440.125
Fusobacterium necrophorum ATCC 25286≤0.03≤0.030.060.25≤0.0310.125
Bilophilla wadsworthia WAL79590.5280.50.50.50.06
Desulfovibrio piger DSM7490.1254160.250.060.1250.25
Capnocytophaga ochracea GAI5586≤0.03≤0.0320.5≤0.030.1252
Veillonella parvula ATCC 107900.1250.50.250.125≤0.030.251
Veillonella dispar ATCC 177480.1250.250.250.06≤0.030.52