TABLE 5.

Effect of benzimidazole nucleosides against various animal CMV strains

VirusDrug50% inhibitory concn (μM)a
Antiviral activityCytotoxicitySIb
MCMVGCV2.9 ± 1.4>36>12
BDCRB371514
1263W94>1150 ± 4<4.5
175X20 ± 6.5158 ± 7.37.9
RCMVGCV31 ± 1.4>361>12
BDCRB26 ± 4.5190 ± 6.57.3
1263W94>1131.6 ± 1.3<3.0
175X28.2 ± 3.8117 ± 124.2
GPCMVCDV1.6 ± 1.0>317>198
GCV191 ± 15>361>1.9
BDCRB2.0 ± 7188 ± 2894
1263W94>5360 ± 9.0<1.1
175X27 ± 8130 ± 44.8
RhCMVGCV22 ± 8>72>3.3
BDCRB0.4>250>625
1263W9448 ± 4.5227 ± 3.74.7
175X6.3 ± 0.8179 ± 1428
  • a Values are expressed as the mean ± standard deviation of at least two plaque reduction assays.

  • b SI, selective index, cytotoxicity in stationary HFF cells/antiviral activity.