TABLE 1.

Effect of benzimidazole nucleosides on alphaherpesvirus replication

Assay for:50% inhibitory concn (μM)a
ACVBDCRB1263W94275175X
Virus
    HSV-14.1 ± 0.9>251>53>50
    HSV-23.5 ± 3.1>251>53>50
    VZV0.7 ± 0.3>50>266>50
Cytotoxicity
    Stationary cellsb>405170 ± 30243152
    Proliferating cellsc>405184 ± 2059 ± 22143 ± 28
  • a Values are expressed as mean ± standard deviation from at least two plaque reduction assays.

  • b Concentration of drug cytotoxic to 50% of HFF cells by neutral red uptake.

  • c Concentrations of drug that inhibit HFF cell growth by 50%.