TABLE 6.

Effect of benzimidazole nucleosides against the gammaherpesviruses

VirusDrug50% inhibitory concn (μM)a
IFA-FACSbDNAELISACytotoxicitySIc
EBVACV17.4 ± 3.63.6 ± 1.29.3 ± 0.4>187>11
BDCRB>125>80>74>125
1263W9410 ± 85.1 ± 4.84.3 ± 0.8>77>7.7
175X18 ± 310 ± 6.8>72>94>5.2
HHV-8CDV10.2 ± 2.5NTdNT>159>16
BDCRB>125NT NT>125
1263W94>133NT NT>80
175X>126NT NT>126
  • a Values are expressed the mean ± standard deviation of at least two assays.

  • b IFA was performed in EBV assays and FACS was performed in HHV-8 assays.

  • c SI, selective index, cytotoxicity in Daudi or BCBL-1 cells/antiviral activity determined by IFA-FACS.

  • d NT, not tested. —, ≤1.