TABLE 3.

Pharmacokinetic parameters of Mycograb in mice given a single dose

Mycograb dose (mg/kg) (sample studied)Cmax (μg/ml)AUC0-t (μg · min/ml)AUC0-∞ (μg · min/ml)t1/2α (min)t1/2β (h)MRT (h)
2 (serum)4.71551573.752.343.17
10 (serum)54.92,857.42,859.67.052.512.35
10 (renal biopsy specimen)21.79,1089,12010.210.949.3