TABLE 4.

MICs of β-lactams for several representative class A ESBL-producing P. aeruginosa isolatesa

β-LactambMIC (μg/ml) for the following extended-spectrum β-lactamase (isolate denomination):
VEB-1 (JES-1)PER-1 (RNL-1)GES-1 (695)GES-2 (GW-1)SHV2a (RP-1)TEM-4 (Stel)IBC-2 (555)
Ticarcillin>512512>512>512>512>512>256
Ticarcillin + CLA25625664>5126432>256
Piperacillin1283251212825632>256
Piperacillin + TZBNAcNA64128168>256
Ceftazidime5121283232328>256
Ceftazidime + CLA1284321684NA
CefotaximeNA64NA128>512128>256
Cefepime128NA1632NA8NA
Imipenem320.511624>128
Meropenem8NANA16NA1>128
Aztrenom>256256416321632
  • a Data were adapted from references 14, 27, 30 to 32, 34, 42, and 45.

  • b CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.

  • c NA, data not available.