TABLE 2

MBCs of different antimicrobial agents for selected Borrelia burgdorferi sensu lato and relapsing-fever Borrelia strainsa

AntimicrobialMBC rangeb (mg/liter)
B. burgdorferi sensu latoRelapsing-fever Borrelia strains
PKoB31HT31LB-2001HS1
Amoxicillin16–326412832>64
Doxycycline8–16>1641–2>4
Ceftriaxone>0.50.25–>1>11–22
Azithromycin0.025>0.05>0.01250.0125≥0.05
Amikacin256–5125126451232–64
  • a MBCs, minimum bactericidal concentrations. PKo, B. afzelii reference strain; B31, B. burgdorferi sensu stricto reference strain; HT31, B. miyamotoi tick isolate (Japan); LB-2001, B. miyamotoi tick isolate (United States); HS1, B. hermsii reference strain.

  • b Ranges are results of tests that were conducted in quadruplicate.