TABLE 3

MICs of different antimicrobial agents for Borrelia burgdorferisensu lato in the literature and the current study

StudyStrain(s) (no.)MethodMIC range (mg/liter)
AmoxicillinDoxycyclineCeftriaxoneAzithromycinAmikacin
Hunfeld et al. (20)VariousReview0.03–20.06–2<0.01–0.1250.003–0.0332–>128
Veinović et al. (18) B. burgdorferi sensu stricto (9)Microscopy0.125–20.125–20.03–0.250.027–0.2232–512
Ruzić-Sabljić et al. (24) B. afzelii (10)Microscopy1–41–40.063–4,00.0138–0.027564–128
Baradaran-Dilmaghani and Stanek (16)B31Microscopy0.20.40.0130.006NDa
Hunfeld et al. (21)PKo and B31Microscopy0.125–0.5b0.250.03<0.01ND
Boerner et al. (29)B31 and N34Microscopy0.06–1b0.125–20.03–0.06<0.016–0.038–32c
This studyPKo and B31Microscopy1–420.06–0.1250.0128256–512
Colorimetric assay0.5–20.125–10.03–0.060.003–0.0256256–512
Hunfeld et al. (21)PKo and B31Colorimetric assay0.015–2b0.06–1<0.01–0.06<0.01–0.06ND
Boerner et al. (29)B31 and N34Colorimetric assay0.06–2b0.125–1<0.016–0.125<0.0164–32c
Morgenstern et al. (25)B31Colorimetric assay0.50.250.030.03dND
  • a ND, not determined.

  • b Penicillin G was used instead of amoxicillin.

  • c Gentamicin was used instead of amikacin.

  • d Erythromycin was used instead of azithromycin.