TABLE 2.

Characteristics of fosfomycin-resistant E. coli mutants isolated in vivo (clinical isolates)

StrainMIC (mg/liter)Growth on carbohydratesGrowth on α-GPGrowth on G6PResistance mutationGenes sequenced
With G6PWithout G6P
DA68861615++NDglpT, uhpT, uhpA, cyaA
DA68833215++uhpT insertion and uhpA deletionglpT, cyaA
DA68874815++NDglpT, uhpT, uhpA, cyaA
DA68844815++NDglpT, uhpT, uhpA, cyaA
DA68744810++NDglpT, uhpT, uhpA, cyaA
DA68854815++uhpT duplicationglpT, uhpT, uhpA, cyaA
DA68904820++NDglpT, uhpT, uhpA, cyaA
DA64396420++NDglpT, uhpT, uhpA, cyaA
DA68916420++NDglpT, uhpT, uhpA, cyaA
DA64359615++NDglpT, uhpT, uhpA, cyaA
DA68969625++NDglpT, uhpT, uhpA, cyaA
DA64409625++uhpT and uhpA deletionglpT
DA6894192>50+uhpA deletion and glpT stop codonglpT, uhpT, uhpA, cyaA
  • a See Table 1, footnotes, b, c, and d.