TABLE 1.

Voriconazole efficacy against 10 C. albicans isolates in a disseminated candidiasis model

C. albicans strainMIC (mg/liter)ED50 (mg/kg/24 h)24-h AUC/ MIC ratio
VoriconzoleFluconazoleTotal drugFree drug
K10.0070.257.9381.417.9
W20.0150.514.19721.2
5800.034.026.323752
98-2100.031616.97616.6
14900.030.519.760.813.3
58100.030.514.350.311.3
2-760.060.252611525.3
21830.06>12824.810222.5
98-170.121628.17215.8
98-2340.253297.526558
Mean ± SD24 ± 17