TABLE 2.

Numbers of genes regulated in M. tuberculosis by each drug's indicated MIC, according to functional class, at 2 and 6 ha

Functional classbTotal no. on array2 h6 h
1×-MIC INH5×-MIC INH1×-MIC TLM5×-MIC TLM1×-MIC TRC5×-MIC TRC1×-MIC INH5×-MIC INH1×-MIC TLM5×-MIC TLM1×-MIC TRC5×-MIC TRC
UpDownUpDownUpDownUpDownUpDownUpDownUpDownUpDownUpDownUpDownUpDownUpDown
0: Virulence, detoxification, adaptation981010101220940214110001913
1: Lipid metabolism23141511415031111610548263131327
2: Information pathways224200215300268491011021008660
3: Cell wall and cell processes6994131144411414424211443446905133
5: Insertion sequences and phages14101000300201210010000120101
6: PE/PPE142000000000000000000000010
7: Intermediary metabolism and respiration889774217615214542322550412605457
8: Unknown265040036112210700100000003211
9: Regulatory proteins18602120111231721012010110254
10: Conserved hypothetical proteins1,0057106214915117424223942141708756
Total3,88025262010783314155924207168983824141516142612288262