TABLE 7

CFU of S. anginosus LMG 14502 killed per biofilm after treatment with cefepime, imipenem, meropenem, or vancomycin with or without addition of DNase I when grown in biofilm medium diluted 1:1 with supernatant of S. aureus LMG 10147a

Antibiotic solution (concn [μg/ml])Log CFU (avg ± SD) killed
Without DNase IWith DNase I (100 μg/ml)
Cefepime (500)1.64 ± 0.241.57 ± 0.40
Imipenem (100)1.74 ± 0.161.68 ± 0.46
Meropenem (500)1.36 ± 0.101.09 ± 0.46
Vancomycin (512)2.13 ± 0.231.97 ± 0.51
  • a n ≥ 3. No significant differences could be observed (P > 0.05).