TABLE 1.

Development of in vitro fluconazole (FCZ) resistance in the five sequential clinical isolates of C. neoformans

Episode (strain)Time of follow-up (mo)Cumulative dose of FCZ (g)MIC (μg/ml)
FCZaFCZbITZaVORa5FCaAMBa
Initial (CN-1)00220.060.5160.12
First relapse (CN-2)201.520.120.0680.25
Second relapse (CN-3)324210.060.06160.12
Third relapse (CN-4)91801.540.120.12320.25
Fourth relapse (CN-5)1533632160.060.25320.12
  • a Determined by microdilution.

  • b Determined by E-TEST.