TABLE 1.

Antimicrobial susceptibility patterns of K. oxytoca 3127, E. coli DH5α clone, and E. coli HB101 transformanta

Antimicrobial agentsK. oxytoca 3127 (parent)E. coli DH5αE. coli DH5α (pBR322-catI-blaKPC-2)E. coli HB101 transformant containing blaKPC-2E. coli HB101
Imipenem32≤0.251615≤0.25
Imipenem-clavulanic acidb4≤0.250.50.5≤0.25
Meropenem32≤0.2588≤0.25
Meropenem-clavulanic acidb4≤0.25≤0.25≤0.25≤0.25
Ampicillin>642>64>644
Amoxicillin-clavulanic acid>32/162/1>32/16>32/162/1
Piperacillin-tazobactam>128/4≤1/4>128/4>128/4≤1/4
Aztreonam>64≤1>64>64≤1
Ceftazidime>64≤23264≤2
Cefoxitin>32232324
Cefpodoxime>160.5>16>16≤0.25
Cefepime>32≤116>32≤1
Cefotaxime>64≤1864≤1
Ceftriaxone>64≤13264≤1
Chloramphenicol84>3244
Gentamicin8≤0.25≤0.258≤0.25
Tobramycin16≤0.25≤0.2516≤0.25
Trimethoprim-sulfamethoxazole>8≤0.12≤0.12≤0.12≤0.12
  • a Values are MICs and are given in micrograms per milliliter.

  • b Clavulanic acid was tested at a fixed concentration of 4μ g/ml.