TABLE 2.

Terbinafine-resistant mutants with single base pair exchanges leading to amino acid substitutions in the Erg1 protein

MutantBase pair exchange in ERG1 geneAmino acid substitution in Erg1 protein
A2M8, H1A, H5, ML3aC751TL251F
H2C1206AF402L
H1BC1260AF420L
H3, H4, H6, H7, H8C1288TP430S
NS2aT1298CF433S
  • a Alleles ML3 and NS2 for terbinafine resistance were isolated after in vitro PCR mutagenesis of the ERG1 gene.