TABLE 1.

Excipients for three prototype vaginal microbicide placebo gels

ExcipientPrototype gelAmt (wt/wt) (%)Function
Water for injection, USPAll100aVehicle
Methylparaben, NFAll0.18Antimicrobial preservative
Propylparaben, NFAll0.02Antimicrobial preservative
EDTA, USPAll0.1Antioxidant
Carbopol 971, NFAll5.0Gelling agent
Propylene glycol, USP1V5.0Emollient
2V1.0
3V0
Glycerin, USP1V5.0Emollient
2V1.0
3V0
2 N NaOH to pH 4.5All9.0pH-adjusting agent
  • a Make up to 100%.