TABLE 3.

Y min values and percent difference in Ymin values generated by use of the Emax (or bell-shaped) model for the metabolic activity of germinated and nongerminated Aspergillus conidia in the presence of echinocandins

Species (no. of strains)Conidial stateMedian (range) Ymin (%)
CaspofunginaMicafunginaAnidulafunginb
A. fumigatus (11)Nongerminated26 (21-50)25 (19-50)26 (21-51)
Germinated26 (13-49)29 (24-55)36 (21-65)
    Differencec3 (−9-11)3 (−14-19)6 (−17-18)
A. terreus (8)Nongerminated34 (14-62)29 (19-64)30 (17-62)
Germinated35 (15-66)37 (16-81)44 (24-76)
    Difference3 (−4-12)7 (−3-18)10 (0-21)
A. flavus (8)Nongerminated17 (14-23)17 (12-22)16 (13-22)
Germinated21 (16-28)20 (18-32)16 (14-22)
    Difference3 (−1-10)5 (−3-13)1 (−7-8)
  • a P was <0.05 for nongerminated A. flavus conidia versus nongerminated A. fumigatus or A. terreus conidia and for germinated A. flavus conidia versus germinated A. terreus conidia.

  • b P was <0.01 for nongerminated A. flavus conidia versus nongerminated A. fumigatus or A. terreus conidia and for germinated A. flavus conidia versus germinated A. fumigatus or A. terreus conidia.

  • c The differences between germinated and nongerminated conidia are expressed here as the percent difference in metabolic activity.