TABLE 3.

Peptide binding to strain set

StrainConcn of drug bound (μg/ml [mean ± SD])a
RP-1 (40 μg)Gramicidin D (32 μg)hNP-1 (20 μg)Daptomycin (6 μg)
616 (parental)12.4 ± 0.4812.0 ± 3.013 ± 1.25.4 ± 0.83
629 (transitional)11.7 ± 0.1010.0 ± 1.84.0 ± 0.5*1.61 ± 1.3*
701 (daptomycin nonsusceptible)11.7 ± 0.1511.0 ± 3.88.0 ± 1.12.32 ± 1.23*
703 (daptomycin nonsusceptible)8.0 ± 0.34*9.0 ± 2.7*8.0 ± 1.62.24 ± 1.07*
  • a *, P < 0.05 versus the parental strain.