TABLE 3.

Ratios of antibiotic concentrations (or AUCs) in ELF or cells compared to serum (or unbound free serum) levelsa

AntibioticCelf/CsCcell/CsCelf/CfsCcell/CfsAUCelf/AUCsAUCcell/AUCsAUCelf/AUCfsAUCcell/AUCfsReference(s)
Beta-lactams
    Amoxicillin0.130.000.160.0034
    Cefdinir0.120.000.350.0032
    Cefdinir0.150.000.440.0032
    Meropenem0.280.250.280.2622
    Meropenem0.430.150.440.1522
Macrolides
    Azithromycin6.30-31.33718.00-6,841.338.18-62.67932.47-13,682.6713.312,284.6920.833,574.8315
    Azithromycin12.63-24.40533.75-1,010.0019.73-48.80833.98-2,020.0021.29748.4634.951,228.5488
    Azithromycin2.53-57.78415.73-9,806.453.28-115.56539.91-19,612.9024.103,234.8134.014,564.6977
    Azithromycin4.60-20.431,756.49-5,242.865.60-26.532,142.06-6,808.915.591,828.548.873,320.0787
    Clarithromycin5.1794.1225.83470.5853,86
    Clarithromycin12.38-20.00141.94-432.1761.89-100.00709.68-2,160.8715.42191.1877.11955.8886,88
    Clarithromycin13.32-60.7598.73-721.4066.59-303.75493.65-3,607.0030.27248.47151.361,242.3421,86
    Clarithromycin10.34-25.29444.94-2,131.5851.70-126.432224.68-10657.8915.33626.3176.653,131.5480,86
    Clarithromycin39.60181.00198.00905.0019,86
    Clarithromycin4.13-38.97169.33-657.6920.65-194.87846.67-3,288.468.34217.5541.711,087.7344
    Telithromycin4.83-14.9142.98-418.1816.08-49.70143.27-1,393.946.44124.9221.48416.4272
    Telithromycin5.38-6.6536.39-154.6017.94-22.16121.29-515.3357
    Telithromycin8.01-14.2237.27-2,019.6326.68-47.39124.23-6,732.089.23338.4730.761128.2460
    Telithromycin2.27-6.2748.94-240.277.57-20.91163.15-800.913.1584.1810.49280.6278
    Cethromycin7.50-20.0067.50-317.5075.00-200.00675.00-3,175.0012.64178.27126.391782.7127
    Cethromycin7.11-10.0090.40-670.0071.05-100.00904.00-6,700.007.87207.4378.742,074.3427
Fluoroquinolones
    Ciprofloxacin0.00-0.8912.36-28.750.00-1.2717.66-41.070.8215.621.17422.3145
    Ciprofloxacin0.902.321.293.3191
    Ciprofloxacin1.857.72.6411.0097
    Ciprofloxacin2.1311.843.0416.919
    Clinafloxacin1.7710.201.8610.7351
    Garenoxacin0.92-1.6510.58-18.273.67-6.5942.33-73.091.3413.895.3855.573
    Gatifloxacin1.51-1.7517.51-36.671.89-2.1921.89-45.841.7724.942.2131.1752
    Grepafloxacin10.49-14.8899.96-268.6515.35-29.76199.92-537.3012.03175.7524.05351.5033
    Levofloxacin1.49-3.005.38-6.142.29-4.618.27-9.452.085.903.209.0715
    Levofloxacin1.17-2.1011.95-23.001.80-3.2418.39-35.381.9415.712.9924.1645
    Levofloxacin0.86-2.268.77-8.941.32-3.4813.50-13.751.908.832.9213.5945
    Levofloxacin0.80-3.004.00-9.601.23-4.626.15-14.772.157.233.3011.135
    Levofloxacin1.53-2.5811.23-17.702.36-3.9717.27-27.231.7512.822.6919.7287
    Levofloxacin1.72-2.0612.47-22.222.64-3.1719.19-34.181.5914.442.4522.2287
    Levofloxacin2.694.904.147.5428
    Lomefloxacin1.8620.472.0722.749
    Moxifloxacin5.18-7.0017.61-70.399.58-12.9632.61-130.365.1813.599.5925.1693
    Moxifloxacin3.61-7.3214.76-55.776.54-13.5627.33-103.284.9227.339.1150.6115
    Pefloxacin13.10-13.4413.78-18.6917.46-17.9118.37-24.9279
    Rufloxacin5.08-11.679.97-27.1712.71-29.1724.93-67.927.6621.5519.1453.8899
    Sparfloxacin8.17-17.0042.63-126.3313.61-28.3371.04-210.5612.6061.2421.00102.07100
    Sparfloxacin12.5044.7520.8374.58100
    Sparfloxacin19.27-65.7129.18-71.6332.12-109.5248.64-119.3931.9340.7153.2267.8591
    Temafloxacin3.135.74.227.7097
    Temafloxacin3.068.814.1411.918
    Trovafloxacin2.16-5.5313.32-22.5516.62-42.54102.46-173.463.6517.5528.09135.014
    Trovafloxacin5.8524.1045.00185.384
Others
    Pyrazinamide13.60-24.760.49-1.0927.20-49.510.98-2.1720
    Ethionamide6.57-10.330.33-0.719.39-14.760.48-1.0230
    Linezolid2.38-4.220.11-0.173.45-6.120.16-0.243.290.154.770.2226
    Linezolid8.350.7112.101.0354
    Itraconazole0.14-0.562.33-5.4414.29-55.56233.33-544.440.222.9421.51293.6025
    Tigecyline1.3277.465.27309.8323
    Rifampin0.17-0.310.71-1.500.83-1.563.54-7.5018
    Rifampin0.3416.261.7081.30103
    Ethambutol0.92-1.1319.17-48.241.22-1.5125.56-64.3126
    Isoniazid fast acetylator1.74-5.881.48-13.421.74-5.881.48-13.4229
    Isoniazid slow acetylator1.37-5.690.74-4.401.37-5.690.74-4.4029
    Rifapentine0.14-0.240.18-0.386.14-10.607.67-16.350.210.269.2811.1231
  • a Cs, serum concentration; Cfs, free serum concentration; AUCs, area under the concentration-time curve in serum.