TABLE 2.

Physical and chemical properties of the antibiotics investigated

AntibioticProtein binding (%)PC (log)Mol wtKaReferencesb
Amoxicillin200.614365.410.8270a, S
Cefdinir60-73−0.725395.420.3969, S
Meropenem2−0.6383.460.5670a, M
Azithromycin7.1-503.329748.981.3670a, S
Clarithromycin803.159747.951.3270a, S
Cethromycin905.24765.931.7665, S
Telithromycin705.0938121.722, S
Ciprofloxacin301.308331.340.9770a, S
Clinafloxacin2-71.63365.791.0312, S
Garenoxacin751.615426.411.0242, S
Gatifloxacin201.586375.391.0269, S
Levofloxacin30-401.485361.371.0070a, S
Lomefloxacin102.334351.351.1812, S
Moxifloxacin39-521.974401.431.1069, S
Pefloxacin252.164333.361.1570a, S
Rufloxacin601.894363.411.0912, S
Sparfloxacin402.866392.41.2912, S
Trovafloxacin871.566416.351.0112, S
Grepafloxacin502.261359.391.1712, S
Pyrazinamide50−0.368123.110.6670a, S
Ethionamide301.220166.240.9870a, S
Linezolid31−0.923337.350.5069, S
Itraconazole99.83.291705.631.3570a, S
Tigecycline79-892.09585.651.1123, M
Rifampin800.486822.940.7670a, S
Ethambutol10-40−0.053204.310.7170a, S
Isoniazid0−0.887137.140.5570a, S
Rifapentine97.71.981877.031.0755, S
  • a Constant K = 0.96 + 0.091·ln (PC·MW−1/2).

  • b S, SciFinder Scholar database (American Chemical Society; 2004); M, MDL quantitative structure-activity relationship (Elsevier Science, Inc.; 2004).