TABLE 2.

Cutoff used by the reference laboratory for interpretation of in vitro susceptibility assays

MoleculeIC50 cutoff value (nM) used to define an isolate as:Reference(s)
SusceptibleIntermediateResistant
Chloroquine<8080-100>1002, 5, 28, 29
Monodesethyl amodiaquine<4040-60>605, 28, 29
Quinine<300300-500>5005, 28
Mefloquine<1515-30>302, 28, 29
Halofantrine<44-8>81, 28, 29
Doxycycline>9.6a29
Atovaquone<55-7>729
Artemether>12; >30b10, 26, 28
  • a For doxycycline, the IC50 is expressed in μM.

  • b Defined as the mutant isolate with the PfATPase6 gene S769N polymorphism.