TABLE 1.

In vitro susceptibilities of yeast isolates used in this study to FLU, AMB, CAS, and POS

IsolatesaMedian MIC in μg/ml (range) for ofb:
FLUAMBCASPOSc
C. parapsilosis ATCC 220194.0 (2.0-4.0)1.0 (1.0)0.25 (0.25)≤0.03 (≤0.03)
C. glabrata 4198>64 (>64)0.5 (0.5-1.0)0.25 (0.06-0.25)0.5 (0.5-2.0), 0.5 (0.5-1.0)*, 1.0 (0.5-2.0)†
C. glabrata 42051.0 (1.0-4.0)0.5 (0.25-0.5)0.25 (0.25)≤0.03 (≤0.03), ≤0.03 (≤0.03-0.06)*, 0.06 (≤0.03-0.06)†
C. glabrata 429332 (32-64)0.5 (0.5)≤0.03 (≤0.03-0.06)0.25 (0.125-0.25), 0.25 (0.125-0.25)*, 0.125 (0.125-0.25)†
C. glabrata 437016 (8.0-16)1.0 (1.0-2.0)0.125 (0.125)0.06 (0.06-0.125), 0.06 (0.06-0.125)*, 0.125 (0.06-0.25)†
  • a Each isolate was tested five times.

  • b Readings were performed spectrophotometrically at either 24 or 48 h with an automatic plate reader (ELx800; Biotek) set at 490 nm. The results were similar (within one double dilution). MICs refer to 48-h readings for POS, FLU, and AMB and to 24-h readings for CAS.

  • c *, Susceptibility to POS after overnight exposure of yeast isolates to AMB at their respective one-half MIC; †, susceptibility to POS after overnight exposure of yeast isolates to CAS at their respective one-half MIC.