TABLE 2.

In vitro activity of POS against C. glabrata 4293 by the halo assaya

TreatmentbMean halo diam (mm) ± SD of POS tested at:
5 μg/disk15 μg/disk
Unexposed cells29.0 ± 2.530.0 ± 1.9
Exposed to CAS at one-half the MIC26.8 ± 0.429.0 ± 1.2
Exposed to CAS at one-eighth the MIC28.0 ± 1.029.6 ± 0.5
Exposed to AMB at one-half the MIC28.4 ± 1.729.8 ± 0.4
Exposed to AMB at one-half the MIC27.0 ± 0.730.0 ± 0.0
  • a C. glabrata 4293 was tested in five independent experiments. Readings were performed at either 24 or 48 h. The results were identical, and 24-h readings are shown in the table.

  • b C. glabrata 4293 was grown overnight in drug-free RPMI 1640 medium (unexposed cells) or medium containing CAS or AMB at one-half the MIC (0.015 and 0.25 mg/ml, respectively) or one-eighth the MIC (0.00375 and 0.0625 mg/ml, respectively).