TABLE 2.

Summary of Cox proportional hazards model results

Time periodParameteraHazard ratio95% Confidence intervalCoefficientSEP
Time to healing of the investigator-confirmed qualifying recurrenceTreatment1.2290.778-1.9420.20650.233150.376
Sex0.7330.458-1.174-0.31020.239980.196
Age1.1920.759-1.8720.17550.239340.446
Duration of last recurrence0.6910.429-1.111-0.37000.242620.127
Baseline HSV-1 serostatus0.7900.492-1.266-0.23540.240410.327
Time to cessation of HSV shedding of the investigator-confirmed qualifying recurrenceTreatment1.4710.786-2.7540.38620.319870.227
Sex0.8370.442-1.586-0.17760.325790.586
Age1.6030.872-2.9450.47180.310380.129
Duration of last recurrence1.0690.571-1.9990.06640.319500.835
Baseline HSV-1 serostatus1.5410.828-2.8660.43230.316630.172
  • a Comparisons: treatment, resiquimod versus vehicle; sex, male versus female; age, ≤40 years versus >40 years; duration of last recurrence, ≤6 days versus >6 days; baseline HSV-1 serostatus, positive versus negative.