TABLE 2.

Geometric mean atazanavir, ritonavir, and tenofovir plasma pharmacokinetic parametersa

DrugValue (geometric mean [95% CI])
AUC0-24 (ng·hr/ml)Cmax (ng/ml)C24 (ng/ml)CL/F (liter/hr)
Atazanavir35,971 (30,853-41,898)3,504 (2,978-4,105)578 (474-704)8.3 (7.2-9.7)
Ritonavir7,840 (6,292-9,769)842 (664-1,064)71 (53-102)12.8 (10.3-16)
Tenofovir2,762 (2,392-3,041)254 (221-292)60 (52-68)49.2 (43.8-55.3)
  • a Pharmacokinetics for 22 subjects were measured.