TABLE 2.

Average FICi by Scedosporium spp. per antifungal combinationa

CombinationbScedosporium apiospermumScedosporium prolificans
MICMECMICMEC
FICiNo. (%) of strains showing synergyFICiNo. (%) of strains showing synergyFICiNo. (%) of strains showing synergyFICiNo. (%) of strains showing synergy
AMB plus 5-FC1.800/12 (0)NCcNC2.00/12 (0)NCNC
AMB plus TBF2.00/12 (0)NCNC2.00/12 (0)NCNC
AMB plus ITC0.931/12 (8.3)NCNC2.00/12 (0)NCNC
AMB plus VRC0.682/12 (16.6)NCNC1.142/12 (16.6)NCNC
AMB plus POS0.792/12 (16.6)NCNC1.890/12 (0)NCNC
AMB plus RVC0.823/12 (25)NCNC1.510/12 (0)NCNC
AMB plus CPF1.262/12 (16.6)0.681/12 (8.3)2.00/12 (0)0.892/12 (16.6)
AMB plus MCF1.870/12 (0)0.854/12 (33.3)2.00/12 (0)1.550/12 (0)
AMB plus ADF1.520/12 (0)1.300/12 (0)2.00/12 (0)1.020/12 (0)
5-FC plus ITC1.841/12 (8.3)NCNC2.00/12 (0)NCNC
5-FC plus VRC1.831/12 (8.3)NCNC2.00/12 (0)NCNC
5-FC plus POS1.860/12 (0)NCNC2.00/12 (0)NCNC
5-FC plus RVC1.841/12 (8.3)NCNC2.00/12 (0)NCNC
5-FC plus CPF2.00/12 (0)2.00/12 (0)2.00/12 (0)2.00/12 (0)
5-FC plus MCF2.00/12 (0)2.00/12 (0)2.00/12 (0)2.00/12 (0)
5-FC plus ADF2.00/12 (0)1.870/12 (0)2.00/12 (0)1.880/12 (0)
TBF plus ITC0.664/12 (33.3)NCNC2.00/12 (0)NCNC
TBF plus VRC1.440/12 (0)NCNC1.133/12 (25)NCNC
TBF plus POS1.090/12 (0)NCNC1.910/12 (0)NCNC
TBF plus RVC0.891/12 (8.3)NCNC1.013/12 (25)NCNC
TBF plus CPF1.291/12 (8.3)1.571/12 (8.3)1.380/12 (0)0.651/12 (8.3)
TBF plus MCF1.890/12 (0)0.995/12 (41.7)2.00/12 (0)1.851/12 (8.3)
TBF plus ADF1.810/12 (0)1.910/12 (0)2.00/12 (0)1.771/12 (8.3)
ITC plus CPF0.2412/12 (100)0.2912/12 (100)2.00/12 (0)1.320/12 (0)
ITC plus MCF0.546/12 (50)0.248/12 (66.6)2.00/12 (0)2.00/12 (0)
ITC plus ADF1.440/12 (0)0.544/12 (33.3)1.910/12 (0)2.00/12 (0)
VRC plus CPF0.623/12 (25)0.418/12 (66.6)2.00/12 (0)1.412/12 (16.6)
VRC plus MCF0.871/12 (8.3)0.367/12 (58.3)2.00/12 (0)1.560/12 (0)
VRC plus ADF1.730/12 (0)0.660/12 (0)2.00/12 (0)1.141/12 (8.3)
POS plus CPF0.398/12 (66.6)0.399/12 (75)2.00/12 (0)1.700/12 (0)
POS plus MCF0.925/12 (41.7)0.396/12 (50)2.00/12 (0)1.890/12 (0)
POS plus ADF1.730/12 (0)0.662/12 (16.6)2.00/12 (0)1.790/12 (0)
RVC plus CPF0.3511/12 (91.7)0.3410/12 (83.4)2.00/12 (0)0.755/12 (41.7)
RVC plus MCF0.387/12 (58.3)0.2811/12 (91.7)2.00/12 (0)2.00/12 (0)
RVC plus ADF0.477/12 (58.3)0.446/12 (50)2.00/12 (0)1.630/12 (0)
  • a The table shows results after two repetitions performed on different days.

  • b AMB, amphotericin B; 5-FC, flucytosine; TBF, terbinafine; ITC, itraconazole; VRC, voriconazole; POS, posaconazole; RVC, ravuconazole; CPF, caspofungin; MCF, micafungin; ADF, anidulafungin.

  • c NC, not calculated.