TABLE 3.

In vitro susceptibility for paired isolates tested at both the ring and the trophozoite stagesa

AntimalarialP. falciparumP. vivax
No. of isolatesMedian IC50 value (range) at the ring stageMedian IC50 value(range) at the trophozoite stageP valueNo. of isolatesMedian IC50 value(range) at the ring stageMedian IC50 value(range) at the trophozoite stageP value
Chloroquine636.1 (11.9-55.0)99.7 (19.6-157.8)0.04955.2 (18.3-171.8)2812 (384-4611)0.008
Amodiaquine68.2 (2.6-16.2)15.2 (5.9-22.4)0.028916.6 (6.7-37.9)24.2 (12.5-59.9)0.05
Mefloquine64.6 (2.1-12.0)6.4 (2.4-34.1)0.07597.9 (1.3-24.6)12.5 (1.9-25.0)0.123
  • a In vitro susceptibility for paired isolates was tested at both the ring(>90%) stage and after culture in the absence of the drug to the trophozoite stage (>90%).