TABLE 1.

PKs of vancomycin and daptomycin achieved with each isolate testeda

S. aureus strainAntibiotic regimenCmax (mg/liter)Cmin (mg/liter)Half-life (h)MIC (mg/liter)AUC0-24/MIC (broth) ratio for D
VD
MSSA 616V 1 g every 12 h31.7 ± 0.410.3 ± 0.27.4 ± 0.910.125536.4 ± 7.8
D 6 mg/kg daily106.8 ± 5.415.9 ± 0.48.4 ± 1.210,005.9 ± 248.9
D 10 mg/kg daily160.2 ± 4.525.5 ± 5.49.3 ± 1.614,480.8 ± 831.6
MRSA 675V 1 g every 12 h32.9 ± 0.410.4 ± 0.27.2 ± 0.320.25277.1 ± 0.6
D 6 mg/kg daily107.2 ± 2.914.1 ± 0.98.0 ± 0.74,990.2 ± 86.7
MRSA 36132V 1 g every 12 h31.4 ± 0.29.4 ± 2.66.9 ± 1.020.25257.4 ± 9.9
D 6 mg/kg daily109.3 ± 3.717.3 ± 5.38.8 ± 1.05,003.6 ± 118.8
MRSA WB1V 1 g every 12 h32.8 ± 0.39.5 ± 0.66.6 ± 0.620.25271.8 ± 4.4
D 6 mg/kg daily98.3 ± 0.212.7 ± 0.67.9 ± 0.04,689.8 ± 19.2
MRSA WB2V 1 g every 12 h33.4 ± 1.56.8 ± 1.85.3 ± 0.620.25243.3 ± 3.2
D 6 mg/kg daily106.1 ± 6.312.4 ± 3.97.6 ± 2.05,643.5 ± 180.0
  • a V, vancomycin; D, daptomycin.