TABLE 3.

AUCs of free drug (unbound to plasma protein) compared to measured and previously published MICs

DrugFree AUC (μg · h/ml)Actual MIC (μg/ml)Published MIC90 (μg/ml)Free AUC/actual MICFree AUC/ published MIC90
Levofloxacin96.510.51.0193.0296.51
295.860.51.0591.72295.86
109.330.51.0218.67109.33
89.830.51.0179.6689.83
91.160.51.0182.3391.16
109.350.51.0218.69109.35
96.511.01.096.5196.51
266.240.51.0532.48266.24
77.260.51.0154.5377.26
82.480.51.0164.9682.48
    Median0.51.0187.6796.51
    Mediana0.51.0180.9993.84
Gatifloxacin35.720.10.5357.1771.43
30.460.20.5152.3160.92
28.880.20.5144.3957.75
44.010.20.5220.0788.03
26.890.20.5134.4453.77
36.050.20.5180.2572.10
35.860.20.5179.2971.71
36.980.20.5184.9273.97
26.890.20.5134.4453.78
24.620.10.5246.2349.25
    Median0.20.5179.7766.18
Moxifloxacin25.670.50.551.3351.33
39.130.50.578.2778.27
27.170.50.554.3354.33
18.320.50.536.6436.64
21.080.50.542.1642.16
29.680.50.559.3559.35
31.510.50.563.0263.02
30.960.50.561.9361.93
30.780.50.561.5761.57
    Median0.50.559.3559.35
  • a Excluding the two patients with the highest values.