TABLE 1.

Results of renal histological examinationsa

Type of abnormalityControl group (n = 8)20-mg/kg/8-h CMS group (n = 9)30-mg/kg/12-h CMS group (n = 11)150-mg/kg/12-h CMS group (n = 8)b
No. of animals showing lesionSeverity of lesionNo. of animals showing lesionSeverity of lesionNo. of animals showing lesionSeverity of lesionNo. of animals showing lesionSeverity of lesion
Protein/cellular casts in proximal tubule0N/A51+31+, 2+, 3+83+
Cortical proximal convoluted tubule necrosis0N/A0N/A31+, 2+73+
Pallor of outer stripe of proximal tubule0N/A0N/A23+0N/A
Intracellular mineralization0N/A0N/A0N/A73+
Nuclear pyknosis0N/A0N/A21+73+
Interstitial nephritis0N/A0N/A21+0N/A
Total no. of animals showing lesions0578
  • a A scale of 1+, 2+, and 3+ corresponding to mild, moderate, and severe changes, respectively, was used to grade lesion severity. N/A, not applicable.

  • b Rats received one dose only and were euthanized on day 1.