TABLE 2.

Overall in vitro sensitivity for each drug according to the species tested

DrugP. vivaxP. falciparum
No. of acceptable assays/ total no. of assays harvested (%)aGeometric mean IC50 value (nM) (95% CI)No. of acceptable assays/total no. of assays harvested (%)Geometric mean IC50 value (nM) (95% CI)
Chloroquine155/170 (91.2)295 (227-384)170/221 (77)47.4 (42.2-53.3)
Amodiaquine143/144 (99.3)15.4 (12.7-18.7)120/137 (88)5.59 (4.96-6.29)
Artesunate136/149 (91.3)1.31 (1.07-1.59)127/157 (81)0.64 (0.53-0.79)
Lumefantrine54/64 (83)19.3 (13.2-28.0)101/124 (82)10.2 (7.6-13.9)
Mefloquine108/108 (100)12.7 (10.3-15.5)146/166 (88)8.5 (6.98-10.4)
Piperaquine125/137 (91.2)21.9 (18.5-25.8)165/200 (83)14.5 (13.2-16.1)
  • a Values shown are the total number of assays with acceptable IC50 values/number of assays harvested.