TABLE 1.

Susceptibility results of 24 clinical isolates of Scedosporium spp.

Antifungal agentMIC or MEC (μg/ml)a
Scedosporium apiospermumScedosporium prolificans
RangeModebGeometric mean50%90%RangeModeGeometric mean50%90%
Amphotericin B0.25->16.04.04.874.016.02.0->16.016.013.916.0>16.0
Flucytosine>64.0>64.0>64.0>64.0>64.0>64.0>64.0>64.0>64.0>64.0
Itraconazole0.25->8.08.03.284.0>8.02.0->8.08.0>8.08.0>8.0
Voriconazole0.12->8.01.00.931.04.01.0->8.08.0>8.0>8.0>8.0
Ravuconazole0.50->8.04.03.924.0>8.02.0->8.0>8.0>8.0>8.0>8.0
Posaconazole0.12->8.01.01.181.0>8.01.0->8.0>8.0>8.0>8.0>8.0
Terbinafine4.0->16.016.0>16.016.0>16.08.0->16.016.0>16.016.0>16.0
Caspofungin>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0
Caspofunginc0.03->16.08.02.560.50>16.01.0->16.01.06.568.0>16.0
Micafungin>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0
Micafunginc0.03->16.00.030.390.12>16.00.03->16.0>16.02.698.0>16.0
Anidulafungin>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0>16.0
Anidulafunginc0.50-4.01.01.191.04.01.0-4.04.04.04.04.0
  • a The table displays average results of two repetitions performed on different days.

  • b Mode, most frequent MIC value.

  • c MEC values are shown in this row.