Final stratified Cox proportional hazards model for time to occurrence of nephrotoxicitya

ParameterHazard ratio95% Confidence intervalP value
Wt of ≥101.4 kg3.652.52-5.28<0.0001
CrCl of ≤86.6 ml/min3.662.12-6.320.020
ICU at initiation of treatment1.951.38-2.760.050
  • a The final log likelihood was −140.97, and the treatment stratum P value was <0.0001 (Mantel test). All covariates were dichotomous. The overall P value was <0.0001.