TABLE 1.

Ranges, MIC50s, and MIC90s of antimicrobial agents for coryneform bacteria and L. monocytogenes

Organism (n)DrugMIC (μg/ml)
Range50%90%
C. amycolatum (31)Tigecycline≤0.015-0.50.1250.25
Doxycycline0.03-10.060.5
Minocycline≤0.03-0.50.060.25
Tetracycline0.06-160.1250.5
Clindamycin0.06->16>16>16
Vancomycin0.125-0.50.250.5
Levofloxacin0.06->32>32>32
Cefuroxime0.125->320.52
Gentamicin0.06->32816
C. jeikeium (25)Tigecycline≤0.015-0.125≤0.0150.03
Doxycycline≤0.015-40.031
Minocycline0.06-0.50.060.25
Tetracycline0.06-80.062
Clindamycin>16>16>16
Vancomycin0.06-0.250.060.25
Levofloxacin0.06->324>32
Cefuroxime2->32>32>32
Gentamicin0.06->32>32>32
C. minutissimum (9)Tigecycline≤0.015-0.003≤0.015NAa
Doxycycline0.06-10.25NA
Minocycline≤0.03-1≤0.03NA
Tetracycline0.125-20.25NA
Clindamycin0.06->16>16NA
Vancomycin0.125-0.250.25NA
Levofloxacin≤0.03->320.06NA
Cefuroxime0.25-160.5NA
Gentamicin≤0.03-40.06NA
C. pseudodiphtheriticum Tigecycline≤0.015-0.06≤0.0150.03
    (22)Doxycycline≤0.015-0.250.1250.125
Minocycline≤0.03-0.060.060.06
Tetracycline0.06-0.50.1250.25
Clindamycin≤0.015->16>16>16
Vancomycin0.06-0.50.250.25
Levofloxacin0.06-320.254
Cefuroxime≤0.03-20.060.125
Gentamicin≤0.03-10.060.06
C. striatum (59)Tigecycline≤0.015-10.51
Doxycycline0.06->168>16
Minocycline≤0.03-1648
Tetracycline0.06->3216>32
Clindamycin≤0.03->16>16>16
Vancomycin0.125-20.250.5
Levofloxacin≤0.03->32>32>32
Cefuroxime0.125->3212
Gentamicin0.06->3228
C. urealyticum (23)Tigecycline≤0.015-0.250.030.06
Doxycycline≤0.015-160.1254
Minocycline≤0.03->320.060.5
Tetracycline≤0.03->320.2516
Clindamycin≤0.015->16>16>16
Vancomycin≤0.03-0.50.250.5
Levofloxacin≤0.03->32>32>32
Cefuroxime4->32>32>32
Gentamicin0.06->32>32>32
C. xerosis (5)Tigecycline≤0.015-0.1250.125NA
Doxycycline0.125-10.5NA
Minocycline0.03-0.250.25NA
Tetracycline0.06-10.5NA
Clindamycin0.125->16>16NA
Vancomycin0.125-0.50.25NA
Levofloxacin0.125-3232NA
Cefuroxime0.125-22NA
Gentamicin≤0.03-168NA
A.haemolyticum(26)Tigecycline≤0.015-0.06≤0.015≤0.015
Doxycycline≤0.015-160.1258
Minocycline≤0.03-4≤0.034
Tetracycline≤0.03-160.12516
Clindamycin≤0.015-0.03≤0.015≤0.015
Vancomycin0.125-0.50.250.5
Levofloxacin0.125-10.50.5
Cefuroxime0.06->320.1250.25
Gentamicin0.25-10.50.5
R. equi (20)Tigecycline≤0.015-0.50.250.5
Doxycycline≤0.015-411
Minocycline0.06-0.50.250.25
Tetracycline0.06-1688
Clindamycin0.03->1628
Vancomycin0.125-20.50.5
Levofloxacin0.125-212
Cefuroxime0.25-16816
Gentamicin0.125-20.51
L. monocytogenes (42)Tigecycline0.03-0.250.060.125
Doxycycline0.03-20.1250.125
Minocycline≤0.03-40.060.06
Tetracycline0.06-40.50.5
Clindamycin0.125-412
Vancomycin0.125-20.51
Levofloxacin0.125-20.51
Cefuroxime4->32>32>32
Gentamicin≤0.03-20.250.125
  • a NA, not applicable (less than 10 isolates tested).