TABLE 5.

Number of strains for which the MICs of isavuconazole (BAL4815) by Etest differed by ± 1, ±2, and >±3 log dilutions from those obtained by the CLSI M38-A and M27-A2 procedures

Genus or species (no. of isolates)No. of isolates for which the Etest MICs differed by the following no. of log dilutions:% Within ±1 log2 dilutiona% Within ±2 log2 dilutionsb
≥−3−2−10+1d+2≥+3
Aspergillus spp.
    A. fumigatus (602)692612551754.8297.18
    A. flavus (34)15188270.5994.12
    A. niger (32)1227271.8793.75
    A. terreus (25)812580.00100
    Other (9)124233.3377.78
    Overall (702)1843152792356.9896.73
Zygomycetes
    Mucor (21)31781171.4380.95
    Rhizopus (12)326175.0075.00
    Absidia (6)131183.33100
    Cunninghamella (4)21175.00100
    Syncephalastrum (2)20100
    Overall (45)61101935171.1184.44
Scedosporium spp.
    S. prolificans (6)6100100
    S. apiospermum (16)13216.2518.75
    Overall (22)1326131.8240.91
Fusarium spp. (20)14491165.0085.00
Candida spp.
    C. albicans (69)c22347104185.5194.20
    C. parapsilosis (84)3313631191.6796.43
    C. glabrata (37)151458462.0089.12
    C. tropicalis (15)21263173.3386.67
    Other (7)1685.7185.71
    C. krusei (5)211180.0080.00
    Overall (217)77251381913784.3393.09
  • a Percentage of strains included between dilutions −1 and +1.

  • b Percentage of strains included between dilutions −2 and +2.

  • c One strain of C. albicans did not grow on RPMI agar.

  • d MIC by the E-test 1 dilution step lower.