TABLE 4.

In vitro activities of isavuconazole (BAL4815) against all fungi, determined by the Etesta

Genus or species (no. of isolates)Isavuconazole MIC
90%50%Range
Aspergillus spp.
    A. fumigatus (602)0.50.250.047-4
    A. flavus (34)0.50.380.016-0.5
    A. niger (32)0.750.50.094-1
    A. terreus (25)0.50.380.094-0.5
    Other (9)0.02-1.5
    Overall (702)0.50.250.002-4
Zygomycetes
    Mucor (21)>3220.19->32
    Rhizopus (12)>3210.5->32
    Absidia (6)0.25->32
    Cunninghamella (4)0.38->32
    Syncephalastrum (2)0.25-0.5
    Overall (45)>3210.19->32
Scedosporium spp.
    S. prolificans (6)>32
    S. apiospermum (16)>32>321->32
    Overall (22)>32>321->32
Fusarium spp. (20)>32>320.38->32
Candida spp.
    C. albicansb (69)0.0150.0040.002-0.125
    C. parapsilosis (84)0.0230.004<0.002-0.125
    C. glabrata (37)0.380.0940.006-6
    C. tropicalis (15)0.1250.0150.003-0.25
    Other (7)0.004-0.16
    C. krusei (5)0.012-0.38
    Overall (217)0.1250.006<0.002-6
  • a All values are expressed in micrograms per milliliter.

  • b One strain of Candida albicans did not grow on RPMI agar plates.