TABLE 2.

Cross-resistances associated with mutation G2576T in the 23S rRNA genes of S. aureus

AntibioticMIC (mg/liter) or strain sensitivitya
T991T2019
Linezolid1128
Erythromycin>256>256
Clindamycin>256>256
Quinupristin-dalfopristin0.56
Doxycycline66
Tigecycline10.75
Gentamicin256256
Fusidic acid0.190.5
ChloramphenicolS (22 mm)R (0 mm)
  • a Data were determined by the Etest method. MICs are given as the medians of the results of three experiments. S, susceptible; R, resistant. Zones of inhibition were determined by the disc diffusion method according to CLSI guidelines (4). Inhibition zone diameters are given in parentheses.