TABLE 5.

Sensitivity of S. aureus RN4220 transformed with plasmids harboring erm(B) and/or cfr to clindamycin, quinupristin-dalfopristin, tylosin, josamycin, and spiramycin

Plasmid (phenotype)aMIC (μg/ml)b
CLIQ-DTYLJOSSPI
pMS2 [erm(B)+cfr+]>1,0240.396,000>2,000>4,000
pLI50 [erm(B)cfr]<1<0.1118
pLXM1 [erm(B)cfr+]1,0240.39264128
pMS2X2 [erm(B)+cfr]>1,024<0.12,000>2,000>4,000
  • a erm(B)+, erm(B) positive; cfr+, cfr positive; erm(B), erm(B) negative; cfr, cfr negative.

  • b CLI clindamycin; Q-D, quinupristin-dalfopristin; TYL, tylosin; JOS, josamycin; SPI, spiramycin.