TABLE 1.

Antimicrobial activities of mBD-14 and hBD-3 against various microorganisms

StrainaMBCb (μM) of mBD-14LD90 (μM) of protein
mBD-14hBD-3c
Gram-positive bacteria
    Staphylococcus aureus ATCC 126001.20.08-0.150.15
    Staphylococcus aureus ATCC 33593 (MRSA)2.40.300.6
    Staphylococcus epidermidis ATCC 149902.41.20.15
    Streptococcus pyogenes ATCC 123441.20.151.2
    Enterococcus faecalis ATCC 292121.20.08-0.15
    Enterococcus faecalis ATCC 51299 (VRE)2.40.30
Gram-negative bacteria
    Escherichia coli ATCC 117750.60-1.20.08-0.15
    Escherichia coli ATCC 259221.20.300.02
    Escherichia coli ESBL 4 (clinical isolate)0.600.150.15
    Salmonella enterica serovar Typhimurium ATCC 133111.20.15
    Pseudomonas aeruginosa ATCC 101451.2-2.40.300.30
    Pseudomonas aeruginosa Va 6201/2000 (multiresistant; clinical isolate)4.80.600.15
    Burkholderia cepacia ATCC 25416>19>19>19
    Burkholderia cepacia ATCC 17759>19>19
    Burkholderia stabilis NCTC 13011>19>19
Yeast
    Candida albicans ATCC 244331.210.60
  • a MRSA, methicillin-resistant Staphylococcus aureus; VRE, vancomycin-resistant enterococcus.

  • b MBC, minimal bactericidal concentration.

  • c LD90s of hBD-3 were calculated based on the work of Sahly et al. (15).